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A Phase IIb Randomised, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Tolerability of AZD6234 in Participants Living With Obesity or Overweight With Comorbidity

A Phase IIb Randomised, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Tolerability of AZD6234 compared with placebo, given once a week as subcutaneous injection for 32 weeks, in male and female participants of at least 18 years of age who are living with obesity (body mass index [BMI] 30 kg/m2 or more, or BMI 27 kg/m2 or more) or overweight and at least one weight-related comorbidity - APRICUS

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCT2051240175
Enrollment
21
Registered
2024-10-31
Start date
2024-11-22
Completion date
Unknown
Last updated
2025-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

Drug : AZD6234 Drug : Placebo

Sponsors

Ageishi Yuji
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: - Adults 18 years of age or more - BMI of (a) 30 kg/m2 or more, or (b) 27kg/m2 or more and have a current diagnosis of at least 1 weight-related comorbidities (treated or untreated) - A stable body weight for 3 months prior to Screening (+-5% body weight change)

Exclusion criteria

Exclusion criteria: - Have obesity induced by other endocrine disorders, such as Cushing's syndrome or Prader-Willi syndrome - Has received prescription or non-prescription medication for weight loss within the last 3 months prior to Screening - Previous or planned (within study period) bariatric surgery or fitting of a weight loss device (eg, gastric balloon or duodenal barrier) - History of type 1 diabetes mellitus or T2DM

Design outcomes

Primary

MeasureTime frame
- Percent change in body weight from baseline to week 26 - Weight loss 5% or more from baseline weight to week 26

Countries

Australia, Canada, Japan, Poland, United Kingdom, US

Contacts

Public ContactYuji Ageishi

Astrazeneka K.K

RD-clinical-information-Japan@astrazeneca.com+81-6-4802-3533

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Feb 4, 2026