Diabetic Peripheral Neuropathy
Conditions
Interventions
Drug: LY3556050
Administered orally.
Drug: Placebo
Administered orally.
Study Arms
Experimental: LY3556050 Dose 1
Participants will receive LY3556050 orally.
Intervention: Drug: LY3556050
Experimenta
Sponsors
Masaki Takeshi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Have a history and current diagnosis of Type 1 Diabetes (T1D) or Type 2 Diabetes (T2D) diagnosed for at least 6 months prior to screening. Have a stable glycemic control on stable diabetes treatment regimen for at least 90 days prior to day 1 with a hemoglobin A1c (HbA1c) =40 and =6 months and diagnosed by a score of Part B >=3 on Michigan Neuropathy Screening Instrument Are willing to maintain a consistent regimen of any ongoing nonpharmacologic pain-relieving therapies (for example, physical therapy) and will not start any new nonpharmacologic pain-relieving therapies during study participation. Are willing to discontinue all medications taken for chronic pain conditions, except allowed concomitant pain medication permitted per protocol, for the duration of the study Have a body mass index <=45 kilogram/square meter (kg/m2) (inclusive). Are men, or women able to abide by reproductive and contraceptive requirements.
Exclusion criteria
Exclusion criteria: History of other potentially causative and/or confounding sources of pain that may impair self-assessment of pain due to DPNP. Have had a procedure within the past 6 months intended to produce permanent sensory loss in the target area of interest (for example, ablation techniques. Have had cancer within 2 years of baseline, except for cutaneous basal cell or squamous cell carcinoma resolved by excision. Are, in the judgment of the investigator, actively suicidal and therefore deemed to be at significant risk for suicide. Have in the judgement of the investigator, an acute, serious, or unstable medical condition or a history or presence of any other medical illness that would preclude study participation. Have a positive HIV test result at screening. Have a surgery planned during the study for any reason. Have a substance use disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders (5th edition; DSM-5; American Psychiatric Association)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean Change from Baseline for Average Pain Intensity Numeric Rating Scale (API-NRS) [ Time Frame: Baseline, Week 12 ] | — |
Countries
Czechia, Japan, Korea, Republic of, Poland, United States
Contacts
Public ContactTrial Guide Call Center
Eli Lilly Japan K.K.
Outcome results
None listed