cerebral hemorrhage Chronic, hemorrhage, brain
Conditions
Interventions
Sponsors
Kawabori Masahito
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age between 20 and 70 years 2. Clinical diagnosis of intracerebral hemorrhage 12 month or more from onset 3. Hemorrhagic location of unilateral basal ganglia or thalamus 4. Moderate to severe neurological symptoms; mRS 3 or 4, and Brunnstrom stage III or IV 5. No significant neurological impairment before hemorrhage (Pre-hemorrhagic mRS of 0 or 1) 6. Subjects who can give informed consent by its self
Exclusion criteria
Exclusion criteria: 1. Severe microbleeds 2. Hemorrhagic cavity less than 2 mL 3. The hemorrhage is due to arteriovenous malformation, cerebral aneurysm, and Moyamoya disease 4. Subject showing obvious communication between the hemorrhagic cavity and lateral ventricle on MRI 5. Subject showing severe lower extremity contracture (Maximum knee extension less than -15 degrees, Maximum ankle flexion less than 0 degree) 6. Subject's body weight less than 45 kg for male and 40kg for female
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety of HUFF-01 up to 1 year after transplantation | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety of HUFF-01 up to 1 week after transplantation Neurological assessments Radiographycal assessments | — |
Contacts
Public ContactMasahito Kawabori
Hokkaido University Hospital
Outcome results
None listed