Identification of the molecular basis of anti-cancer effect of Huaier.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1091220335

Enrollment

Registered

2018-03-05

Start date

2018-02-09

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancers such as hepatocellular carcinoma, breast cancer, colorectal cancer and related gastrointestinal cancers, urologic cancers including prostate cancer, pancreas cancer, and lung cancer), on which a significant therapeutic efficacy of Huaier has been reported. Special remarks is emphasized on the cancer cases designated to be related to cancer stem cells.

Interventions

Intervention type:DRUG Name of intervention:Huaier Dose form / Japanese Medical Device Nomenclature:GRANULES Route of administration / Site of application:ORAL Dose per administration:20? g Dosing fre

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Diagnosed as cancer and will be obtained follow-up data and healthy persons

Exclusion criteria

Exclusion criteria: Taking other medicines or supplements.

Design outcomes

Primary

Measure	Time frame
For mRNA libraries, focus on mRNA studies. Data analysis includes sequencing data processing and basic sequencing data quality control, prediction of new transcripts, differential expression analysis of genes. Gene Ontology (GO) and the KEGG pathway database are used for annotation and enrichment analysis of up-regulated genes and down-regulated genes. For small RNA libraries, data analysis includes sequencing data process and sequencing data process QC, small RNA distribution across the genome, rRNA, tRNA, alignment with snRNA and snoRNA, construction of known miRNA expression pattern, prediction New miRNA and Study of their secondary structure Based on the expression pattern of miRNA, we perform not only GO / KEGG annotation and enrichment, but also different expression analysis.	—

Measure

Time frame

For mRNA libraries, focus on mRNA studies. Data analysis includes sequencing data processing and basic sequencing data quality control, prediction of new transcripts, differential expression analysis of genes. Gene Ontology (GO) and the KEGG pathway database are used for annotation and enrichment analysis of up-regulated genes and down-regulated genes. For small RNA libraries, data analysis includes sequencing data process and sequencing data process QC, small RNA distribution across the genome, rRNA, tRNA, alignment with snRNA and snoRNA, construction of known miRNA expression pattern, prediction New miRNA and Study of their secondary structure Based on the expression pattern of miRNA, we perform not only GO / KEGG annotation and enrichment, but also different expression analysis.

—

Secondary

Measure	Time frame
Based on subtle expression results and small RNA and mRNA prediction results, we perform integrated analysis to identify related small RNA and mRNA.	—

Countries

Japan

Contacts

Public ContactTomoo Tanaka, M.D., Ph.D.

Bradeion Institute of Medical Sciences, Co. Ltd.

ttanaka@bradeion.com+81-463-58-0952

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026