Fixed-dose combination of losartan and hydrochlorothiazide significantly improves endothelial function in uncontrolled hypertension by low dose amlodipine

Fixed-dose combination of losartan and hydrochlorothiazide significantly improves endothelial function in uncontrolled hypertension by low dose amlodipine - FCLH

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1091220222

Enrollment

Registered

2015-08-20

Start date

2015-08-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The investigation on the effect of medication in patients with uncontrolled hypertension on endothelial function

Interventions

Intervention type:DRUG Name of intervention:Medication Dose form / Japanese Medical Device Nomenclature:TABLET Route of administration / Site of application:ORAL Dose per administration:50mg12.5mg 50m

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: uncontrolled hypertension despite use of amlodipine (2.5 mg daily)

Exclusion criteria

Exclusion criteria: Severe compliocations, malignancy, acute illness

Design outcomes

Primary

Measure	Time frame
endothelial function	—

Secondary

Measure	Time frame
blood pressure decrease	—

Countries

Japan

Contacts

Public ContactBonpei Takase

National defense medical college

takaseb-18@ndmc.ac.jp+81-4-2995-1511

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026