Effect of remifentanil infusion rate on stress response in orthopedic surgery using a tourniquet application

Effect of remifentanil infusion rate on stress response in orthopedic surgery using a tourniquet application - Effect of remifentanil infusion rate on stress response in orthopedic surgery using a tourniquet application

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1091220094

Enrollment

Registered

2012-07-25

Start date

2010-09-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The subjects were 20 patients aged over 16years with American Society of Anesthesiologists (ASA) physical status I-II undergoing orthopedic surgery of the lower limbs (knee joint) using a tourniquet application.

Interventions

Intervention type:DRUG Name of intervention:remifentanil hydrochloride Dose form / Japanese Medical Device Nomenclature:INJECTION Route of administration / Site of application:INTRAVENOUS DRIP Dose pe

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria:

Exclusion criteria

Exclusion criteria: poorly controlled hypertension, abnormal glucose tolerance with 5.5% or higher HbA1c, past medical history of steroid hormone administration, requirement of intraoperative blood transfusion, past medical history of narcotic analgesic administration, and complications of Parkinson's disease.

Design outcomes

Primary

Measure	Time frame
drenocorticotropic hormone (ACTH), cortisol, Blood pressure, heart rate,antidiuretic hormone (ADH), adrenaline (Ad), noradrenaline (NAd), dopamine (DOA), insulin, and blood glucose	—

Countries

Japan

Contacts

Public ContactTaketo Shinoda

Showa University Fujigaoka Hospital

shinoda@an.em-net.ne.jp+81-45-974-6675

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026