Non-invasive treatment for severe chronic constipation and megacolon due to hyperactive internal anal sphincter

Non-invasive treatment for severe chronic constipation and megacolon due to hyperactive internal anal sphincter - NOTHIAS

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1091220089

Enrollment

Registered

2012-06-08

Start date

2012-06-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe chronic constipation, megacolon

Interventions

Intervention type:DRUG Name of intervention:NOTHIAS (Non-invasive treatment for severe chronic constipation and megacolon due to hyperactive internal anal sphincter) Dose form / Japanese Medical Devic

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with severe chronic constipation with high anal pressure accompanying ultra-slow waves in manometric study.

Exclusion criteria

Exclusion criteria: Presence of heart diseases including heart failure, arrhythmia, angina pectoris, etc. Hirschsprung disease, Secondary anal stenosis after surgery, Patients who can't measure the dose of ointment applied the perineum. If such patient is in aid of personnel managing the treatment, he (she) could be enrolled in the study.

Design outcomes

Primary

Measure	Time frame
Spontaneous bowel movement	—

Secondary

Measure	Time frame
Decrease of anal pressure and disappearance of anal ultra-slow waves in manometric study	—

Countries

Japan

Contacts

Public ContactHiroyuki Kayaba

Hirosaki University Graduate School of Medicine

kayaba@cc.hirosaki-u.ac.jp+81-172-39-5123

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026