Efficacy of Enamel Matrix Derivative/ Freeze-Dried Bone Allograft VS Enamel Matrix Derivative/ Demineralized Freeze-Dried Bone Allograft with or without Forced Eruption Treating Infrabony Defects: Two Randomized Trials

Efficacy of Enamel Matrix Derivative/ Freeze-Dried Bone Allograft VS Enamel Matrix Derivative/ Demineralized Freeze-Dried Bone Allograft with or without Forced Eruption Treating Infrabony Defects: Two Randomized Trials - RCT

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1090220077

Enrollment

Registered

2012-01-06

Start date

2004-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronoc periodontitis

Interventions

Intervention type:DRUG,PROCEDURE Name of intervention:EMD alone vs EMD/FDBA vs EMD/DFDBA with or without forced eruption Dose form / Japanese Medical Device Nomenclature:NOT APPLICABLE,OTHER Route of

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 6mm>CAL and radiographic bone loss

Exclusion criteria

Exclusion criteria: 1) systematic diseases influencing periodontal surgery; 2) systematic medications affecting periodontal status; 3) pregnancy or lactation; 4) smoker; 5) sensitivity to minocycline and tetracycline.

Design outcomes

Primary

Measure	Time frame
The primary outcome measurewas absolute change in PD reduction and CAL gain from baseline to 1-year and 3 years follow-up.	—

Secondary

Measure	Time frame
OPAL gain from baseline to 6 month	—

Countries

Japan

Contacts

Public ContactShigeki Ogihara DDS,Ph.D.

Ogihara Dental Clinic/ Periodontics &Implat Dentistry

oshigeki@fantasy.plala.or.jp+81-3-3849-8483

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026