A study to examine the efficacy of mannitol in partial nephrectomy

A comparative study to examine the effect of mannitol administration during partial nephrectomy on preserving renal function

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1071250065

Enrollment

Registered

2025-09-04

Start date

2025-09-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal cell carcinoma

Interventions

Patients will be randomly divided into two groups , with or without mannitol injection before and after clamp. Mannitol is administrated intravenously in 100ml over 3-10minutes under the direction of

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1 planned pertial nephrectomy for RCC 2 planned renal scintigram 3 preoperative eGFR 45=< 4 informed consent has been obteined 5 age 18=<

Exclusion criteria

Exclusion criteria: 1 with contralateral nephrectomy or solitary kidney 2 clinical stage 2=< 3 acute intracranial hematoma

Design outcomes

Primary

Measure	Time frame
Postoperative renal function preservation rate on the resected side	—

Secondary

Measure	Time frame
4weeks or 24 weeks postoperative total renal function	—

Contacts

Public ContactKojiro Ohba

Nagasaki University Hospital

ohba-k@nagasaki-u.ac.jp+81-958197340

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026