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Nutrient supplementation during orthopedic surgery procedures : essential amino acids and zinc benefits

Nutritional supplementation at perioperative period of orthopedic surgery: usefulness of essential amino acids and zinc

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCT1071250050
Enrollment
50
Registered
2025-07-24
Start date
2025-08-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Musculoskeletal diseases (degenerative diseases of extremity joints and spine, traumatic injuries) Musculoskeletal diseases

Interventions

Participants in the treatment group will receive essential amino acids and zinc (VCRESC Cp10) in addition to the hospital meal starting the day after surgery. The non-intake group will receive the hos

Sponsors

Haruta Yohei
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients receiving surgical treatment for musculoskeletal diseases at our hospital from August 1, 2025 to July 31, 2027

Exclusion criteria

Exclusion criteria: Patients with oral intake difficulties, patients with a history of nutritional malabsorption disorders (ulcerative colitis, Crohn's disease, etc.), patients with postoperative higher brain dysfunction or tetraplegia, patients who required reoperation within 1 week after surgery, patients with a history of allergy to VCRESC Cp10.

Design outcomes

Primary

MeasureTime frame
The Prognostic Nutrition Index (PNI) will be calculated from the total blood lymphocyte count and serum albumin concentration and compared between the groups.

Secondary

MeasureTime frame
The amount of change in blood counts and biochemical tests (including hemoglobin concentration, total lymphocyte count, serum albumin concentration, and total cholesterol level) will be compared between groups between groups. Patient background (including clinical score) and surgical data (operation time, blood loss amounts, etc.) will be compared between groups, divided by the correlation between postoperative food intake and changes in perioperative nutritional status, and the presence of complications (delirium, postoperative infection, deterioration of general condition, conditions requiring reoperation or other treatment) within 3 months after surgery.

Contacts

Public ContactHideki Mizu-uchi

Saiseikai Fukuoka General Hospital

mizuuchi.hideki.243@m.kyushu-u.ac.jp+81-92-771-8151

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026