Therapeutic effect to supplementation with glycine for isovaleric acidemia

Therapeutic response to supplementation with glycine for isovaleric acidemia

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1071220102

Enrollment

Registered

2023-01-31

Start date

2020-04-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Isovaleric acidemia abnormal metabolism of organic acid

Interventions

After taking informed consent, study items such as medical history, physical findings, imaging tests, and blood tests are performed. Glycine dosage should be started at 100~250 mg/kg/day, and the dosa

D046650

Isovaleric acidemia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients diagnosed with isovaleric acidemia between March 2006 and March 2023 are able to attend the University of the Ryukyu Hospital.

Exclusion criteria

Exclusion criteria: Patients or their representatives request refusal to participate this studay.

Design outcomes

Primary

Measure	Time frame
Number of acute metabolic crisis	—

Secondary

Measure	Time frame
Degree of blood acidosis, intelligence testing, blood biochemicals: ammonia, glycine, free carnitine.	—

Contacts

Public ContactYasutsugu Chinen

Graduate School of Medicine, University of the Ryukyus

ychinen@med.u-ryukyu.ac.jp+81-98-895-1154

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026