Acute respiratory distress syndrome ARDS, acute respiratory distress syndrome, ECMO, extracorporeal membrane oxygenation
Conditions
Interventions
Eligible participants were randomly assigned to the high PEEP group or low PEEP group.
High PEEP group
PEEP are set to 15 cm H2O from the start of V-V ECMO support until the liberation trial from V-V
D011175
PEEP, positive end-expiratory pressure, mechanical ventilation
Sponsors
Ohshimo Shinichiro
Nishikimi Mitsuaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients (18-80 years old) with ARDS requiring V-V ECMO
Exclusion criteria
Exclusion criteria: 1. Had been converted from V-A ECMO 2. Had been on a ventilator for longer than 7 days 3. Hemodynamically unstable with LVEF below 40 percent 4. Pneumothorax or air leak syndrome 5. ARDS due to thoracic trauma 6. ARDS due to extra-pulmonary reason 7. Known pregnancy 8. Were judged by the ICU attending doctors as being unsuitable to participate in this study based on their medical condition
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ECMO-free days during the first 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| mortality at 28 days, in-hospital mortality at 60 days, ventilator-free days during the first 60 days, length of ICU stay | — |
Contacts
Public ContactMitsuaki Nishikimi
Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
Outcome results
None listed