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Evaluating the Efficacy of Elobixibat Hydrate in Preparing Patients with Chronic Constipation for Colonoscopy

A Multicenter Randomized Controlled Trial Evaluating the Efficacy of Elobixibat Hydrate in Preparing Patients with Chronic Constipation for Colonoscopy

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCT1061260004
Enrollment
192
Registered
2026-04-06
Start date
2026-04-06
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic constipation

Interventions

The study group will take Goofice 10 mg/day starting 3 days prior to colonoscopy. The control group will not take Goofice. Both groups will take picosulfate sodium the night before. Subsequently, on t

Sponsors

Oka Shiro
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Patients scheduled to undergo colonoscopy 2) Patients aged 18 years or older at the time of consent acquisition 3) Individuals for whom written informed consent for participation in this study can be obtained 4) Patients diagnosed by a physician with chronic constipation who meet two or more items of the ROMA-IV criteria for constipation and are in a chronic state

Exclusion criteria

Exclusion criteria: 1) Patients already taking Goofice 2) Patients with suspected gastrointestinal obstruction or intestinal obstruction 3) Patients with suspected intestinal perforation, gastric stasis, or toxic megacolon 4) Patients with inflammatory bowel disease 5) Patients who have undergone ileocecal resection or total colectomy 6) Women who are pregnant or may be pregnant, women who are breastfeeding, or women who wish to become pregnant 7) Patients with a history of hypersensitivity to Goofice, picosulfate sodium, or any component of Moviprep 8) Other patients deemed ineligible for enrollment in this study by the principal investigator or sub-investigator

Design outcomes

Primary

MeasureTime frame
Total volume of Moviprep and water consumed until completion of bowel preparation

Secondary

MeasureTime frame
Quality of bowel preparation Evaluation of bowel movements during the 3 days prior to the procedure and on the morning of the procedure Time required for bowel preparation and assessment of acceptability of Moviprep Evaluation of adverse events during the study period

Contacts

Public ContactTakeshi Takasago

Hiroshima University Hospital

takasago@hiroshima-u.ac.jp+81-82-257-5190

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026