Alzheimers disease
Conditions
Interventions
Oral medication, brexpiprazole
Sponsors
ISHIKAWA Ichiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The subjects were patients who were diagnosed with Alzheimer's type dementia and who required medication adjustments for hospitalization due to a strong focus, and who were admitted to the researcher's affiliated institution. Among the above patients, all of the following must also be met. 1) Diagnosis of Alzheimer's disease 2) Over 70 years old 3) Must have a score of 6 or higher excitement or irritability items before administration NPI. 4) The patient's physical condition is current and has not caused any major abnormality in the past year (malignant tumor, etc.)
Exclusion criteria
Exclusion criteria: Those who fall under any of the following will be excluded. 1) Have a disease that affects sleep quality or daytime alertness 2) Have a physical illness that makes it difficult to complete the research 3) Meet diagnostic criteria for schizophrenia, mood disorder, delirium, etc. 4) Already taking other antipsychotics or benzodiazepine sleeping pills
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in sleep structure due to PSG before and 4 weeks after brexpiprazole administration Total sleep time, sleep onset latency, mid-awakening time, sleep stage ratio, periodic leg movement index, apnea-hypopnea index. | — |
Secondary
| Measure | Time frame |
|---|---|
| NPI score, Athens Insomnia Scale | — |
Contacts
Public ContactIchiro ISHIKAWA
Kagawa university faculty of medicine
Outcome results
None listed