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Validation of concomitant medications affecting lamotrigine blood levels

Validation of concomitant medications affecting lamotrigine blood levels

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCT1061220093
Enrollment
40
Registered
2023-02-01
Start date
2023-02-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bipolar disorder, epilepsy

Interventions

Patients with psychiatric disorders who have been taking lamotrigine (Lamictal) for at least 2 weeks and have reached steady state will be included in the study and will be treated with the same pharm

Sponsors

Ishizawa Keisuke
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. cases in which LTG was prescribed for the treatment of psychiatric disorders in our psychiatry department 2. cases in which the patient (or a substitute) has given written consent

Exclusion criteria

Exclusion criteria: 1. patients under 18 years of age 2. patients for whom it is impossible to measure LTG blood concentration due to the unavailability of samples necessary for the measurement 3. patients whose consent could not be obtained 4. other patients deemed ineligible by the physician in charge

Design outcomes

Primary

MeasureTime frame
Based on the data obtained, the population pharmacokinetics of lamotrigine in epilepsy patients will be used to estimate trough values, AUC, etc., to evaluate the effect on LTG concentrations in concomitant drugs.

Contacts

Public ContactHiroshi Bando

Tokushima University Hospital

bando.hiroshi.2@tokushima-u.ac.jp+81-88-633-9385

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026