decompensated liver cirrhosis with carnitine deficiency
Conditions
Interventions
Intervention group: L-carnitine 1500mg/day medication for 12
weeks. The dose increase and decrease is possible.
non-intervention group: non administration of L-carinitine
Sponsors
Takaki Akinobu
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The decompensated liver cirrhosis patients with Child-Pugh score over 7 points, and satisfy the following criteria. 1. over 20 years old 2. written informed consent 3. can periodically go to hospital
Exclusion criteria
Exclusion criteria: 1. already take carinitine 2. The blood concentration of total carinitine and free carinitine is higher than the normal upper limit value 3. with a history of any hypersensitivity to ingredients in L-Cartin FF tablets and Levocarnitine FF tablets. 4. pregnant, unwilling to practice contraception during the study 5.. lactating female 6. The patient who received other study medicine or the clinical experimental medicine within three months before start of this study 7. The investigator judged to be inappropriate as the study subject
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the improvement rate of Child-Pugh score | — |
Secondary
| Measure | Time frame |
|---|---|
| the change of grasping power, serum ammonia, neuropsychological test,subjective symptom, increase or decrease medication, safety | — |
Contacts
Public ContactTakuya Adachi
Okayama University Hospital
Outcome results
None listed