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A study on the effects of knowing one's alcohol sensitivity on alcohol consumption and drinking behavior among workers

Effects of Providing Genetic Information Related to Alcohol-Metabolizing Enzymes on Alcohol Reduction and Behavioral Change Among Workers: A Randomized Controlled Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCT1060260033
Enrollment
400
Registered
2026-06-24
Start date
2026-07-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Not applicable to a specific disease (Alcohol drinking habits in the workplace or healthy workers).

Interventions

The intervention consists of providing feedback on alcohol-metabolizing enzyme-related genes. - Intervention Group: Participants receive standard informational leaflets along with feedback on their a

Sponsors

Kinjo Aya
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Workers aged 20 years or older at the time of obtaining informed consent. 2) Workers with a habit of drinking alcohol at least once a month at the time of obtaining informed consent.

Exclusion criteria

Exclusion criteria: 1) Workers who have ever received specialized medical treatment for alcohol use (such as brief intervention clinics/moderation programs or specialized dependency treatment facilities) from the past to the present. 2) Workers who do not wish to receive feedback regarding their alcohol-metabolizing enzyme-related genes (ADH1B, ALDH2). 3) Workers who are pregnant or lactating.

Design outcomes

Primary

MeasureTime frame
1) Change in weekly alcohol consumption from baseline to 12 months post-intervention. 2) Change in Alcohol Use Disorders Identification Test (AUDIT) and AUDIT-C scores from baseline to 12 months post-intervention.

Secondary

MeasureTime frame
1) Change in weekly alcohol consumption, AUDIT scores, and AUDIT-C scores from baseline to 6 months post-intervention. 2) Change in the proportion of participants from baseline to 6 and 12 months post-intervention for the following items: - Proportion of participants whose weekly alcohol consumption decreased by 25% or more, or 50% or more, compared to baseline. - Proportion of participants whose AUDIT scores decreased by 25% or more, or 50% or more, compared to baseline. - Proportion of participants who engage in Heavy Episodic Drinking (HED). - Proportion of participants whose stage of change (transtheoretical model) improved by one stage or more. 3) Change in clinical health examination results and the proportion of participants with abnormal values at 12 months post-intervention for the following: body mass index (BMI), waist circumference, blood pressure, liver function tests, blood glucose tests, serum lipid levels, and liver fibrosis index (FIB-4 Index). 4) Subjective impact of the feedback on alcohol-metabolizing enzyme-related genotypes on the participants' own drinking behavior within the intervention group.

Contacts

Public ContactAya Kinjo

Tottori University

kinjo_aya@tottori-u.ac.jp+81-859-38-6103

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026