OHCA patients receiving ECPR Out-of-Hospital Cardiac Arrest
Conditions
Interventions
- Hypothermia group: Ttemperature control at 33-34 degree Celsius
- Normothermia group: Ttemperature control at 36 degree Celsius
D001831
Sponsors
Inoue Akihiko
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Out-of-hospital cardiac arrest 2) Age of 18-75 years, known or as estimated 3) Initial cardiac arrest rhythm of ventricular fibrillation/pulseless ventricular tachycardia or pulseless electrical activity
Exclusion criteria
Exclusion criteria: 1) ECMO initiated after sustained return of spontaneous circulation (ROSC), patients with sustained ROSC before ECMO initiation 2) OHCA of presumed non-cardiac etiology 3) Time from emergency call or witnessed arrest to hospital arrival > 60 minutes 4) Time from hospital arrival to ECMO initiation > 60 minutes 5) Prehospital ECPR 6) Unavailability of the ECMO heat exchanger for temperature control 7) Glasgow Coma Scale (GCS) before temperature control >8 8) Core body temperature upon hospital arrival under 32 degrees Celsius 9) Surgical intervention before temperature control (e.g., surgical intervention for the primary disease or complications related to resuscitation/ECMO procedures) 10) Do Not Attempt Resuscitation (DNAR) order confirmed prior to temperature control 11) Limitations in intensive care before temperature control 12) Known cerebral performance category (CPC) of 3-4 before cardiac arrest 13) Known chronic obstructive pulmonary disease with home oxygen therapy 14) Known or as estimated pregnancy 15) Concomitant illness such as malignancy shortens life expectancy (180 day survival unlikely) 16) Consent not obtained or withdrawn by the participant or surrogate 17) Other reasons, physician decision not to enroll
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival at hospital discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| - Survival at 30 days, 90 days, and one year after admission - Cerebral Performance Category (CPC) at hospital discharge, 30 days, 90 days, and one year after admission - Serious adverse events (arrhythmia, bleeding, pneumonia, bacteremia) during ICU | — |
Countries
Japan, Taiwan
Contacts
Public ContactYoko Kataoka
Kagawa University Hospital
Outcome results
None listed