The effects of anesthetics on hemodynamics during EVAR: RCT

The effects of remimazolam and sevoflurane on hemodynamics during Endovascular Aneurysm Repair under general anesthesia: A randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1052260053

Enrollment

Registered

2026-05-18

Start date

2022-11-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal Aortic Aneurysm

Interventions

Randomization will be conducted to evaluate the use of remimazolam or sevoflurane as an anesthetic maintenance agent.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 31 patients with abdominal aortic aneurysms undergoing EVAR (Endovascular Aneurysm Repair) under general anesthesia

Exclusion criteria

Exclusion criteria: (1) Patients who are in atrial fibrillation at the time of admission to the operating room and cannot be evaluated for appropriate heart rate variability (2) Dialysis patients (3) Patients taking benzodiazepine medications (4) Patients for whom Anelem is contraindicated (5) Patients for whom sevoflurane is contraindicated

Design outcomes

Primary

Measure	Time frame
AUT (Area Under Threshold), which combines the duration and magnitude of periods when the average blood pressure is below 65 mmHg	—

Secondary

Measure	Time frame
Number of episodes of hypotension Total duration of hypotension Occurrence of severe hypotension (mean arterial pressure < 50 mmHg) Amount of vasopressor used during surgery	—

Contacts

Public ContactOkita Toshikazu

Nara Prefecture General Medical Center

toratora424@gmail.com+81-742466001

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026