Coronary microvascular dysfunction and heart failure after TAVI

A study to elucidate the relationship and pathophysiology of left ventricular hypertrophy and worsening heart failure after TAVI from the perspective of coronary microvascular dysfunction

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1052240127

Enrollment

Registered

2024-09-18

Start date

2024-10-09

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic stenosis, Heart failure, Coronary microvascular dysfunction AS, TAVI, CMD

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adults aged 20 years or older Patients with severe aortic valve stenosis who are eligible for TAVI treatment and are scheduled for TAVI Patients with stenosis findings or suspected stenosis on coronary CT prior to TAVI Cases where informed consent has been obtained from the patient for participation in the study

Exclusion criteria

Exclusion criteria: Presence of severe valvular disease (stenosis or regurgitation) other than aortic valve stenosis Patients who have undergone PCI during the pre-TAVI cardiac catheterization or are scheduled to undergo PCI postoperatively Patients deemed unsuitable for this study by the principal (or sub-investigator) physician

Design outcomes

Primary

Measure	Time frame
CFR and IMR as indicators of coronary microvascular dysfunction before and after TAVI	—

Secondary

Measure	Time frame
Evaluation of the correlation between wire-based IMR and angio-based IMR Transthoracic echocardiography: assessment of the severity of various valvular diseases and left ventricular mass index Cardiac MRI: assessment of left ventricular mass index and Late Gadolinium Enhancement (LGE)	—

Contacts

Public ContactKosuke Fujita

Kindai university hospital

koyumi514@gmail.com+81-9019511351

Outcome results