Aortic stenosis
Conditions
Interventions
Randomization will be used to select remimazolam or propofol as the general anesthetic.
Sponsors
Kotani Taichi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 28 patients with moderate to severe aortic stenosis diagnosed by echocardiography undergoing TAVI (Transvalvular Aortic Valve Implantation) under general anesthesia
Exclusion criteria
Exclusion criteria: (1) Patients undergoing local anesthesia TAVI (2) Patients who cannot speak daily conversation in Japanese (3) Patients who are unable to consent to the study because they do not understand the study description (4) Patients with a pre-existing pacemaker implantation or diabetes mellitus with neuropathy who cannot be evaluated for appropriate heart rate variability (5) Patients who are in atrial fibrillation at the time of admission to the operating room and cannot be evaluated for appropriate heart rate variability (6) Patients with contraindications to the use of Anerem (7) Patients with contraindications to the use of 1% Diprivan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage change in mean HFVI value for 3 minutes before induction of anesthesia and mean HFVI value for 3 minutes immediately after induction of anesthesia | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in hemodynamic parameters during induction of anesthesia Changes in HFVI values during induction of anesthesia to the start of surgery Changes in HFVI values during rapid pacing at the time of TAVI valve insertion | — |
Contacts
Public ContactTaichi Kotani
Nara Medical University
Outcome results
None listed