Primary lung tumor
Conditions
Interventions
deep inspiration breath-hold adaptive radiotherapy
D062485
radiotherapy
deep inspiration breath-hold
adaptive radiotherapy
Sponsors
Takashi Mizowaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged 20 years or older. 2) ECOG-PS of 0 or 1 3) Centrally located lung tumours with a maximum diameter of 5 cm or less, defined according to the IASLC recommendations as tumours located within 2 cm of the mediastinum (including bronchi, oesophagus, heart, brachial plexus, major blood vessels, spinal cord, phrenic nerve, and recurrent laryngeal nerve). 4) Patients who can hold their breath for more than 20 s. 5) Patients who are considered suitable for stereotactic body radiation therapy meet the predefined dose constraints for OARs, as determined by board-certified radiation oncologists. 6) Patients who provide written informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients with interstitial pneumonia 2) Life expectancy of less than 3 months according to estimations by board-certified radiation oncologists 3) Patients who are not capable of giving consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment-related adverse events grade 3 or worse (CTCAE v5.0) | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival rate, disease-free survival rate, local recurrence-free survival rate, quality of life, grade 2 or more severe AEs, 1-year cumulative incidence of grade 2 or more severe radiation pneumonitis, the number of patients and fractions requiring adapted plans, data on dose-volume indices, structures of target volumes and OARs, set-up error, treatment time, quality assurance of planned online adaptive radiotherapy treatment, medical images, and ventilation volume/abdominal wall displacement | — |
Contacts
Public ContactNoriko Kishi
Kyoto University Hospital
Outcome results
None listed