Central Nervous System Diseases neurological disorders
Conditions
Interventions
Forty patients will be randomly divided into two groups in each disability function of neurological disease patients, and assigned 20 patients in the "noninvasive brain stimulation + rehabilitation tr
rTMS, rehabilitation
Sponsors
Hanakawa Takashi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1 Patients who are 18years of age or older at the time of consent to participate in the study and are undergoing medical treatment at the outpatient or inpatient department of Kyoto Ohara Memorial Hospital, Kyoto Konoe Rehabilitation Hospital, Gosyo Minami Rehabilitation Clinic, or Kyoto University Hospital neurology or otorhinolaryngology departments 2 Patients who have developed cerebrovascular disorders, neuromuscular degenerative diseases, involuntary movement diseases, neuromuscular inflammatory diseases , central neurological disorders, or traumatic central neurological disorders, and for whom the diagnosis has been established by neurological findings, imaging findings 3 6 days or more after the onset of symptoms, or 6 days or more after the recurrence of symptoms 4 Patients suffering from any of the following disorders due to neurological diseases: motor disorder (in upper-limb or lower-limb), higher brain dysfunction, language disorder, and dysphagia. 5 Patients who have given a full explanation and have given written consen from the person or proxy if written consent from the person is difficult to obtain.
Exclusion criteria
Exclusion criteria: 1 5 days or more before the onset of symptoms, or 5 days or more before the recurrence of symptoms 2 Patients who are difficult to communicate due to significant hearing impairment 3 Patients who have a cardiac pacemaker 4 Ptients who has metals in the body which cannot be confirmed to be non-magnetic 5 Those who are judged inappropriate as a participant by the "Transcranial Magnetic Stimulation Test / Pre-Checklist" and "MR Test Pre-Checklist". 6 Those who are with claustrophobia 7 Any other person who is judged by the principal investigator to be inappropriate as a research subject
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activity changes in EEG (analysis of EEG amplitude, frequency analysis) | — |
Secondary
| Measure | Time frame |
|---|---|
| Amplitude values in each frequency band of MEG Changes in cerebral blood flow during the task and at rest by fMRI Motor evoked potential by TMS Evaluation of motor and cognitive functions Evaluation of neuroplasticity-related factors (BDNF, myokines) Physical activities Nutrition quantity | — |
Contacts
Public ContactTomoya Gyoda
Kyoto university
Outcome results
None listed