Parkinson's syndrome including Parkinson's disease, stroke, spinocerebellar degeneration neurological disorders
Conditions
Interventions
Repetitive paired TMS includes paired stimuli that stimulate the motor cortex (M1) twice (ipsilateral M1-M1), the M1 and the contralateral M1 (contralateral M1-M1), the cerebellum and the M1 (Cbl-M1)
Sponsors
Hanakawa Takashi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Selection criteria Adults who consent to participate in the study Healthy subjects) Those who have no history of psychiatric disorders and have sufficient understanding and consent. Neurological disease patients) Adult patients who consent to participate in the study and who are undergoing medical treatment at the outpatient department of neurology or inpatient department of Kyoto University Hospital. The target disease is Parkinson's syndrome including Parkinson's disease, stroke, or spinocerebellar degeneration. Adults with 20 years old and over (18 years old and over after April 1, 2022) are targeted, but no other age / gender criteria are set.
Exclusion criteria
Exclusion criteria: Exclusion criteria Healthy subjects) 1 Those who do not give consent to participate in the study 2 Those who have a significant obstacle to communication 3 Those who are judged inappropriate as a participant by the "Transcranial Magnetic Stimulation Test / Pre-Checklist" and "MR Test Pre-Checklist". 4 Those who are with claustrophobia Neurological disease patients) 1 Those who are in a extremely poor general condition (such as abnormal vital signs) 2 Those who do not give consent for the research subject 3 Those who are judged inappropriate as a participant by the "Transcranial Magnetic Stimulation Test / Pre-Checklist" and "MR Test Pre-Checklist". 4 Those who are with claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor evoked potential by TMS | — |
Secondary
| Measure | Time frame |
|---|---|
| Amplitude values in each frequency band of EEG, values measurted by structural and functional 7T-MRI to investigate connectivity between brain regions Eye movement measurement | — |
Contacts
Public ContactTomoya Gyoda
Kyoto university
Outcome results
None listed