Periprocedural Cerebral Embolism by Catheter Ablation of Atrial Fibrillation

A Randomized Study Comparing the Frequency of Periprocedural Cerebral Embolism by Catheter Ablation of Atrial Fibrillation between Cryoballoon and Radiofrequency Ablation (Embo-Abl study)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1052210013

Enrollment

230

Registered

2021-04-30

Start date

2021-05-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atrial fibrillation atrial fibrillation, catheter ablation, cerebral embolism

Interventions

control group: radiofrequency catheter ablation of atrial fibrillation intervention group: cryoballoon ablation of atrial fibrillation

catheter ablation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. aged 20-85 years old 2. diagnosed as atrial fibrillation 3. planned radiofrequency or cryoballoon catheter ablation of atrial fibrillation 4. written informed consent

Exclusion criteria

Exclusion criteria: 1. history of catheter ablation and/or surgery of atrial fibrillation 2. left atrial dimension more than 55 mm 3. inability to take brain MRI 4. pregnant 5. concomittant participation in intervention study with other medication and/or medical instrument 6. patients whom doctors responsible for this study judge inappropriate

Design outcomes

Primary

Measure	Time frame
1. cerebral embolism (silent cerebral events) by brain MRI during the acute phase of catheter ablation	—

Secondary

Measure	Time frame
safety 1. cerebral embolism (silent cerebral lesions) by brain MRI during the acute phase of catheter ablation 2. cerebral embolism by brain MRI 1 month after 3. number of micro-embolic signals during catheter ablation 4. mico-hemorrhag e during the acute phase and 1 month after catheter ablation 5. complication of catheter ablation efficacy 1. success rate of catheter ablation during the acute phase 2. success rate of catheter ablation 1 year after catheter ablation	—

Measure

Time frame

safety 1. cerebral embolism (silent cerebral lesions) by brain MRI during the acute phase of catheter ablation 2. cerebral embolism by brain MRI 1 month after 3. number of micro-embolic signals during catheter ablation 4. mico-hemorrhag e during the acute phase and 1 month after catheter ablation 5. complication of catheter ablation efficacy 1. success rate of catheter ablation during the acute phase 2. success rate of catheter ablation 1 year after catheter ablation

—

Contacts

Public ContactKoji Miyamoto

National Cerebral and Cardiovascular Center

koji3koji3@gmail.com+81-6-6170-1070

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026