atrial fibrillation atrial fibrillation, catheter ablation, asymptomatic
Conditions
Interventions
intervention g roup: catheter ablation of asymptomatic atrial fibrillation
control group: no catheter ablation of asymptomatic atrial fibrillation
atrial fibrillation, catheter ablation, asymptomatic
Sponsors
Kusano Kengo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. aged 20-85 years old 2. asymptomatic atrial fibrillation 3. written informed consent
Exclusion criteria
Exclusion criteria: 1. previous history of catheter ablation and/or surgery of atrial fibrillation 2. left atrial dimension more than 55 mm 3. BNP equal or less than 20pg/ml 4. eGFR less than 30ml/min/1.73m2 5. patients receiving ARNI 6. pregnant 7. concomittant participation in other medication and/or medical instrument 8. patients whom doctors responsible for this study judge inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BNP 12 months after | — |
Secondary
| Measure | Time frame |
|---|---|
| efficacy 1. BNP: 3, 6 months, 2, 3, and 5 years after 2. exercise tolerability: 12 months, 2, 3, 5 years after 3. Cr, CCr, eGFR, cystatin C, urine Na, urine Cr: 3, 6, 12 months, 2, 3, 5 years after 4. left ventricular ejection fraction, left atrial dimension, and left atrial volume: 12 months, 2, 3, 5 years after 5. recurrence rate of atrial tachyarrhythmia, cardiovascular events, total death, death related to cardiovascular events: 6, 12 months, 2, 3, 5 years after 6. success rate of pulmonary vein isolation, total procedure time, left atrial dwelling time, radiation exposure time and dose 7. brain MRI: 1, 3, 5 years after 8. AFEQT and MoCA: 1, 3, 5 years after safery 1. complication and/or side effect of ablation and/or medication | — |
Contacts
Public ContactKoji Miyamoto
National Cerebral and Cardiovascular Center
Outcome results
None listed