Lumbar spinal canal stenosis, lumbar disc herniation, cervical spondylotic myelopathy
Conditions
Interventions
Patients who meet the inclusion criteria and are enrolled will be randomly assigned to the aspirin continuation or discontinuation group.
Sponsors
Tamai Koji
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. patients scheduled for spine surgery (cervical posterior decompression, cervical posterior decompression and fusion, cervical anterior decompression and fusion, lumbar posterior decompression and fusion, lumbar posterior decompression and fusion, lumbar posterolateral fusion) taking aspirin who visited the Osaka Public University Hospital Department of Orthopaedic Surgery and related facilities during the period from the time of jRCT publication to March 2026. 2. Cases where the name of the disease for which the patient was prescribed aspirin could be confirmed, and where it was possible to discontinue the medication before surgery. 3. if the procedure is a fusion surgery, cases of fusion surgery within 2 vertebral levels. 4. patients who are 40 years of age or older at the time of consent 5. patients who are able to make outpatient visits in accordance with the study schedule
Exclusion criteria
Exclusion criteria: 1.Patients taking antiplatelet agents other than aspirin 2.Patients taking multiple antiplatelet agents 3.Patients taking anticoagulants 4. patients with more than three fixed vertebrae 5.Patients with known bleeding disorder 6.Patients undergoing revision surgery 7. cases with tumor, trauma, or infection 8. patients with severe liver disease (AST (GOT) or ALT (GPT) > 100 U) 9. patients with a history of serious drug allergy or serious adverse drug reactions 10. other patients who are judged to be unsuitable as subjects by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total intraoperative and postoperative blood loss | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. operative time, length of hospital stay 2. incidence of hematoma requiring reoperation, dural injury rate, blood transfusion rate, thrombosis rate, and readmission rate within 30 days after discharge 3. preoperative, 3-month postoperative investigator-reported outcome (JOA score), Patient-Reported Outcome (common: VAS score, EQ5D, surgical satisfaction, cervical spine: JOACMEQ, NDI, lumbar spine: JOABPEQ, ODI) | — |
Contacts
Public ContactKoji Tamai
Osaka Metropolitan University Hospital
Outcome results
None listed