A Study Comparing the Effects of Different Methods of Administering Pain Relief for Standard Procedures for Malignant Pleural Mesothelioma

A Prospective Randomized Comparison Trial of Outcomes of Continuous Intertransverse Interproximal Block Indwelling Catheter Administration in Postoperative Analgesia for Pleurectomy/Pulmonary Decortication

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1051240111

Enrollment

Registered

2024-08-20

Start date

2024-04-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant Pleural Mesothelioma

Interventions

Using a random number table, the study patients were divided into two groups: one group received continuous local anesthesia via a continuous nerve block catheter from the beginning of surgery (intrao

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients over 20 years old who will be scheduled for pleurectomy/decortication surgery at the Surgical Center of Hyogo Medical University Hospital during the period from the date of approval to April 30, 2026, who have consented for the placement of a continuous catheter for postoperative pain management, and who have also agreed to participate in the research.

Exclusion criteria

Exclusion criteria: 1.Patients with American Society of Anesthesiologists Physical Status Classification (ASA-PS) of IV or above 2.Patients with severe dementia, difficult to make postoperative assessment 3.Patients with a history of chronic pain or regularuse opioid 4.Patients at high risk of bleeding

Design outcomes

Primary

Measure	Time frame
The assessment of postoperative quality of life	—

Secondary

Measure	Time frame
1.Visual Analog Scale (VAS) at rest and during movement at 1 hour, 24 hours, 48 hours, and 72 hours postoperatively. 2.Numerical Rating Scale (NRS) at rest and during movement at 1 hour, 24 hours, 48 hours, 72 hours, 6 months, and 1 year postoperatively. 3.Intraoperative blood loss. 4.Perioperative opioid usage. 5.Postoperative Patient-Controlled Analgesia (PCA) usage from the continuous catheter. 6.Presence of postoperative nausea and vomiting. 7.Perioperative blood pressure fluctuations and use of vasopressors. 8.Postoperative oxygen supplementation, presence of respiratory complications. 9.Inflammatory markers (CRP, white blood cell count) in blood samples taken the day after surgery. 10.Duration of stay in the intensive care unit, time to ambulation, length of hospital stay postoperatively.	—

Measure

Time frame

1.Visual Analog Scale (VAS) at rest and during movement at 1 hour, 24 hours, 48 hours, and 72 hours postoperatively. 2.Numerical Rating Scale (NRS) at rest and during movement at 1 hour, 24 hours, 48 hours, 72 hours, 6 months, and 1 year postoperatively. 3.Intraoperative blood loss. 4.Perioperative opioid usage. 5.Postoperative Patient-Controlled Analgesia (PCA) usage from the continuous catheter. 6.Presence of postoperative nausea and vomiting. 7.Perioperative blood pressure fluctuations and use of vasopressors. 8.Postoperative oxygen supplementation, presence of respiratory complications. 9.Inflammatory markers (CRP, white blood cell count) in blood samples taken the day after surgery. 10.Duration of stay in the intensive care unit, time to ambulation, length of hospital stay postoperatively.

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Contacts

Public ContactMayuu Kobata

Hyogo medical university hospital

mayurinbusiness.2028@gmail.com+81-798456111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026