Inhibitory effects of high-concentration fluoride on hypersensitivity and caries progression against the initial active root caries lesions: A randomized controlled trial

Inhibitory effects of high-concentration fluoride on hypersensitivity and caries progression against the initial active root caries lesions: A randomized controlled trial - A randomized controlled trial to assess the effects of hign-concentration fluoride on initial active root caries lesions

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1051220182

Enrollment

Registered

2023-03-02

Start date

2023-03-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

initial active root caries

Interventions

application of 2 % sodium fluoride solution or 22600rpm fluoride varnish

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adults who have initial active root caries with hypersesitive symptom.

Exclusion criteria

Exclusion criteria: Patients with significant reduction in salivary flow due to drug side effects, diabetes, Sjogren's syndrome, radiation therapy and so on.

Design outcomes

Primary

Measure	Time frame
hardness of the root dentin	—

Secondary

Measure	Time frame
symptom of hypersensitivity	—

Contacts

Public ContactYoko Asahi

Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry

asahi.yoko.dent@osaka-u.ac.jp+81-6-6879-2927

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026