Severe cancer pain Severe cancer pain
Conditions
Interventions
Continuous subcutaneous titration of opioids is performed. Methods: A 24 G plastic cannula is inserted subcutaneously in the abdomen
continuous subcutaneous administration is performed using a small syringe pump for 10 mL syringes. For pioid naive patients, opioids are infected by flow rates
(1) hydromorphone dissolved at 0.2 mg/mL, starting at 0.20 mL/h and increasing by 0.05 ml/h up to 1.0 ml/h. If the situation requires further increase of hydromorphone, replace with hydromorphone 1.0
Continuous subcutaneous injection
titration of opioids
Sponsors
Kajiyama Toru
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with severe cancer pain (numerial rating scale 7-10) who desired continuous subcutaneous titration with opioid analgesics.
Exclusion criteria
Exclusion criteria: Impaired consciousness, delirium, cognitive impairment, renal impairment, hepatic impairment, poor general condition assessment, gastrointestinal transit disorder, patients under 20 years of age, drug allergy to the study drug, and patients who did not consent to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At least 66% pain reduction of numerical ration scale within 3 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Titration completion rate within 7 days; Titration completion days (days from start to end of continuous subcutaneous administration); Pain intensity at day 7 / Dyspnea / Sleep assessment / Quality of life assessment / Rescue medication use assessment / Adverse events. | — |
Contacts
Public ContactTatsuma Sakaguchi
Kitano Hospital, Tazuke Kofukai Medical Research Institute
Outcome results
None listed