Effect of Remimazolam vs Conventinal Anesthesia on Postoperative Delirium in Patients with Cardiac Surgery

Effect of Remimazolam vs Conventional Anesthesia (Propofol or Desflurane) on Postoperative Delirium in Patients with Cardiac Surgery: Randomized controlled trial - ReDCard trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1051210195

Enrollment

250

Registered

2022-03-17

Start date

2022-03-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart disease Valvular disease, Ischemic heart disease, Hypocardiac function

Interventions

Arm Remimazolam : use Remimazolam as a general anesthesia maintenance drug Arm Placebo : use Propofol or Desflurane as a general anesthesia maintenance drug

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patients with heart disease who need cardiac surgery and have been requested for general anesthesia by cardiovascular surgeons (2) Scheduled procedure is valve replacement/plasty, coronary artery bypass grafting, ventricular assist device insertion/replacement, cardiac tumor resection, or combination surgery. (3) The patients age at the time of obtaining consent is 20 years or older. (4) A written consent of this study has been obtained from the individual.

Exclusion criteria

Exclusion criteria: (1) Patients with cerebrovascular disease within 3 months (2) Patients with drug abuse. (3) Patients undergoing surgery including aortic surgery as combined surgery (4) Patients who require hypothermic circulatory arrest for scheduled procedure (5) Patients with surgery due to congenital heart disease (6) Patients who have contraindication for any anesthetics (7) Patients who are deemed inappropriate as research subjects by the investigators for other reasons

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative delirium up to 5 days after surgery using ICDSC score	—

Secondary

Measure	Time frame
(1) Total amount of circulatory agonist, blood and water balance, usage of IABP/PCPS during the operation (2) Total amount of fentanyl and remifentanil (3) Total amount of target mean arterial blood pressure (50~100mmHg) deviation time (4) rSO2 (5) Perioperative complications (acute kidey injury, stroke/cerebral hemorrhage), myocardial infarction, tracheostomy (6) Perioperative death (7) Perioperative ventilation time, intensive care unit admission period, hospitalization period (8) Anesthesia time, surgery time, cardiopulmonary bypass time, aortic clump time	—

Measure

Time frame

(1) Total amount of circulatory agonist, blood and water balance, usage of IABP/PCPS during the operation (2) Total amount of fentanyl and remifentanil (3) Total amount of target mean arterial blood pressure (50~100mmHg) deviation time (4) rSO2 (5) Perioperative complications (acute kidey injury, stroke/cerebral hemorrhage), myocardial infarction, tracheostomy (6) Perioperative death (7) Perioperative ventilation time, intensive care unit admission period, hospitalization period (8) Anesthesia time, surgery time, cardiopulmonary bypass time, aortic clump time

—

Contacts

Public ContactYuri Hayashi

Osaka University Hospital

kurukuru710@yahoo.co.jp+81-6-6879-3133

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026