Lung tumor etc.
Conditions
Interventions
Use remimazolam or desflurane to maintain general anesthesia
Sponsors
Yamamoto Kasumi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for thoracoscopic pneumonectomy with intraoperative unilateral lung ventilation 2.American Society Association physical status class 1~3 3.Patients who have sufficient judgment to understand the research content and have provided written consent
Exclusion criteria
Exclusion criteria: Patients who meet any of the following conditions are excluded: 1.Scheduled for thoracoscopic pneumonectomy with intraoperative unilateral lung ventilation for less than 2 hours 2.Undergoing bilateral lung surgery 3.History of surgery on the ventilated lung 4.History of hypersensitivity to the following ingredients of remimazolam desflurane or other halogenated anesthetics remifentanil components or fentanyl compounds rocuronium component or bromide 5.History of drug dependence 6.History of malignant hyperthermia or a history of malignant hyperthermia in their relatives 7.Acute angle-closure glaucoma 8.Myasthenia gravis or Congenital myasthenia 9.Muscular dystrophy 10.Severe aortic regurgitation 11.Shock 12.Acute intoxication 13.Received nalmefene hydrochloride within the previous week 14.Continuously receiving antihypotensive agents 15.With a chest tube inserted 16. Interstitial pneumonia 17.Pregnant or breastfeeding 18.Arterial oxygen saturation (SpO2) of less than 95% in room air, or requiring oxygen administration 19.Severe liver dysfunction (serum bilirubin level >2.5 mg / dL or PT activity level <50%) 20.BMI of less than 15 kg/m2 or more than 30 kg/m2 21.QTc is greater than or equal to 450 msec (according to Bazett's correction formula) on preoperative electrocardiogram 22.Arrhythmia more than 3 times per minute on electrocardiogram
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Minimum PaO2 value for 60 min after the start of unilateral lung ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| The following measurements during bilateral lung ventilation and 15 min, 30 min, 45 min, and 60 min after the start of unilateral lung ventilation in the lateral position: average blood pressure / pulse rate / cardiac output / SpO2 / EtCO2 / Etdes arterial blood gas analysis results (pH / PaO2 / PaCO2) total dose of remimazolam from induction of anesthesia | — |
Contacts
Public ContactKasumi Yamamoto
Wakayama Medical University Hospital
Outcome results
None listed