Atopic Dermatitis / Asteatosis / Healthy subjects
Conditions
Interventions
None listed
Sponsors
Fujita Tomoyuki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Group with atopic dermatitis patients Patients over the age of 18 at the time of informed consent. Patients with moderate to severe atopic dermatitis according to the diagnostic criteria of the Atopic Dermatitis Clinical Practice Guidelines. Patients with inflammatory lesions at the sample collection site 2) Group with atopic dermatitis patients Patients over the age of 18 at the time of informed consent. Patients with asteatosis, exhibiting an Overall Dryness Score (ODS) of 2 or higher on the lower legs, and presenting only with signs of dryness 3) Healthy volunteer group Healthy control samples will be utilized from a separate ongoing study (Ref. jRCT1050250006).
Exclusion criteria
Exclusion criteria: 1) Group with atopic dermatitis patients Patients with autoimmune diseases. Patients with skin conditions other than atopic dermatitis at the sample collection site. 2) Group with asteatosis patients Patients with skin conditions other than asteatosis at the sample collection site. Subjects with a history of tape-induced contact dermatitis, mechanical urticaria, or similar conditions. Subjects for whom sampling is deemed difficult due to wounds, tattoos, or other conditions at the sampling site, as determined by the principal investigator. Subjects who have received systemic immunosuppressive therapy (including corticosteroids) within 4 weeks prior to the sample collection date. Subjects who have applied any topical medications or quasi-drugs (such as over-the-counter antibacterial soaps) to the collection site within 1 week prior to the sample collection date. Subjects who have taken a shower or bath within 12 hours prior to the sample collection date. Subjects who have applied skincare products (including antiperspirants, body wipes, body creams, etc.) to the sample collection site within 12 hours prior to the sample collection date. Subjects who have engaged in exercise that causes sweating on the day of sample collection. Subjects who have participated in another clinical trial, post-marketing clinical study, or clinical research involving investigational products within 120 days prior to sample collection, or who are currently participating in such studies. Pregnant or breastfeeding women, or those who might be pregnant. Subjects considered inappropriate for the study by the principal investigator or co-investigators 3) Healthy volunteer group Healthy control samples will be utilized from a separate ongoing study (Ref. jRCT1050250006).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Using tape stripping method, RNA and lipids in the stratum corneum collected from patients with atopic dermatitis, asteatosis, and healthy controls will be measured to identify the optimal analytical method. | — |
Contacts
Public ContactMichio Yagi
Medical Corporation Heishinkai OPHAC Hospital
Outcome results
None listed