Coronary artery disease atheroscleros, inflammation, single cell analysis, RNA-seq
Conditions
Interventions
None listed
Sponsors
Fukuda Daiju
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. scheduled to undergo percutaneous coronary intervention using directional coronary atherectomy (DCA) between the date of jRCT publication and March 2027 at Osaka Metropolitan University Hospital or collaborating institutions 2. diagnosed with coronary artery disease (angina pectoris, asymptomatic myocardial ischemia, unstable angina pectoris, non-ST-elevation myocardial infarction, ST-elevation myocardial infarction) by diagnostic imaging tests (coronary CT, coronary angiography) 3. age 20 years or older at the time of initial consent
Exclusion criteria
Exclusion criteria: 1. patients with unstable respiratory and circulatory status requiring ventilator or mechanical support 2. patients after cardiopulmonary resuscitation 3. patients who are deemed unsuitable for DCA due to highly calcified coronary arteries 4. other patients deemed unsuitable for DCA by the surgeon
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study will perform a comprehensive analysis of coronary plaque specimens in two groups of patients with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS), to elucidate gene expression and related signals involved in plaque destabilization. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints: Comparison of intravascular imaging findings and transcriptome analysis by the following categories 1. clinical diagnosis (myocardial infarction and unstable angina) and CCS 2. presence of plaque rupture/erosion and stratified plaque by optical frequency domain imaging (OFDI) 3. presence of low-absorption-area plaques on coronary computed tomography (CT) 4. coronary CT with/without perivascular adipose tissue attenuation | — |
Contacts
Public ContactKenichiro Otsuka
Osaka Metropolitan University Graduate School of Medicine
Outcome results
None listed