Observational Study of the Effect of Cardiac Rehabilitation on Myokine Dynamics in Patients with HFpEF

Observational Study of the Effect of Cardiac Rehabilitation on Myokine Dynamics in Patients with Heart Failure and Preserved Ejection Fraction

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1050230041

Enrollment

Registered

2023-06-17

Start date

2023-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure heart failure, HFpEF

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who are 20 years old or older and who received written informed consent. Patients with heart failure and preserved ejection fraction who are eligible for outhospital cardiac rehabilitation. Patients who can perform cardiopulmonary excercise test.

Exclusion criteria

Exclusion criteria: Patients who had contraindication to cardiac rehabilitation with excercise. Patients with neuromuscular diseases such as myopathy and chronic inflammatory diseases. Patients who are pregnant or are breastfeeding. Patients who are considered inapproproiate for this research.

Design outcomes

Primary

Measure	Time frame
Serial change in Myokine dynamics during CPX	—

Secondary

Measure	Time frame
composite endopint including cardiovascular death and hreart failure hospitalization parameter of excercise tolerance in CPX Cardiac and skeletal muscle uptake values and WR in Tc-MIBI Late phase H/M ratio and WR in MIBG Skeletal muscle mass and strength Vascular endothelial function Echocardiographic parameters	—

Contacts

Public ContactTakumi Kondo

Division of Cardiology, Osaka General Medical CenterOsaka General Medical Center

takumikondou2000@yahoo.co.jp+81-6-6692-1201

Outcome results