International Risk Assessment of Cnm-positive S. mutans in Stroke and Vascular Dementia Surveillance

International Risk Assessment of Cnm-positive S. mutans in Stroke and Vascular Dementia Surveillance - International-RAMESSES trial

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1050190051

Enrollment

700

Registered

2019-09-19

Start date

2019-09-19

Completion date

Unknown

Last updated

2025-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke, Dementia Stroke, Intracerebral hemorrhage, microbleeds, lacunar stroke, vascular cognitive impairment

Interventions

no-intervention

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Stroke Cohort Study Subjects age >= 18 years old First Ever Stroke (within 5 years from the onset) Diagnosis based on brain imaging (computed tomography or magnetic resonance imaging) A written informed consent has been obtained from the subjects or relatives. Dementia Cohort Study Subjects age 55-85 years old modified Rankin Scale <= 3 0.5<= Clinical Dementia Rating<= 2.0 MMSE score <=23 Evaluation of 3.0 tesla brain MRI imaging within 5 years A written informed consent has been obtained from the subjects or relatives.

Exclusion criteria

Exclusion criteria: Stroke Cohort Study recurrent stroke cases who are difficult to communicate due to unconsciousness cases with no-natural remaining teeth cases judged inappropriated by collaborators. Dementia Cohort Study prevalence of other systemic diseases that clearly affect cognitive function within 3 months cases who are difficult to communicate due to unconsciousness cases with no-natural remaining teeth cases judged inappropriated by collaborators.

Design outcomes

Primary

Measure	Time frame
Stroke Cohort Study Prevalence of Cnm-positive S. mutans in oral cavity (saliva and dental plaque) among subjects with stroke (ischemic stroke, or hemorrhagic stroke). Dementia cohort Prevalence of Cnm-positive S. mutans in oral cavity (saliva and dental plaque) in dementia (Alzheimer disease, vascular dementia, mixed type).	—

Secondary

Measure	Time frame
Stroke Cohort Study The association between prevalence of Cnm-positive S. mutans in oral cavity and the location of ICH (lobar, deep, mixed). the estimated hematoma volume of ICH. Dementia Cohort Study The association between prevalence of Cnm-positive S. mutans in oral cavity and Small vessel disease biomarkers on MRI (white matter lesion, lacunar infarctions, cerebral microbleeds, enlargement of perivascular space) and atrophic change in hippocampus. score of Montreal Cognitive Assessment (MoCA), Minimental State Examination (MMSE) self-reported dental disorder and number of naturally remaining teeth.	—

Measure

Time frame

Stroke Cohort Study The association between prevalence of Cnm-positive S. mutans in oral cavity and the location of ICH (lobar, deep, mixed). the estimated hematoma volume of ICH. Dementia Cohort Study The association between prevalence of Cnm-positive S. mutans in oral cavity and Small vessel disease biomarkers on MRI (white matter lesion, lacunar infarctions, cerebral microbleeds, enlargement of perivascular space) and atrophic change in hippocampus. score of Montreal Cognitive Assessment (MoCA), Minimental State Examination (MMSE) self-reported dental disorder and number of naturally remaining teeth.

—

Countries

Japan, Kenya, Nigeria, Singapore

Contacts

Public ContactShuichi Tonomura

National Cerebral and Cardiovascular Center

tonomura.shuichi58@ncvc.go.jp+81-6-6170-1070

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Feb 4, 2026