Randomized Controlled Trial of the Modified Killian Method

Randomized Controlled Phase II Trial of the Modified Killian Method Using an Ultra-thin Endoscope for Pharyngeal Examination

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1042250216

Enrollment

Registered

2026-03-25

Start date

2026-03-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and neck squamous cell carcinoma and esophageal squamous cell carcinoma (high-risk population) Head and neck squamous cell carcinoma, esophageal squamous cell carcinoma

Interventions

Hypopharyngeal observation will be performed using an ultrathin endoscope. Participants will undergo both the conventional Valsalva method and the Modified Killian method in a randomized crossover des

D308

Procedure

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with a history of esophageal squamous cell carcinoma or head and neck squamous cell carcinoma 2. Age over 18 years 3. Written informed consent obtained

Exclusion criteria

Exclusion criteria: 1. Advanced cancer in the pharyngolaryngeal region 2. Inability to maintain a sitting position 3. Cervical spine disorders preventing neck movement 4. Pregnancy or suspected pregnancy 5. Patients judged inappropriate by investigators

Design outcomes

Primary

Measure	Time frame
Hypopharyngeal visibility score assessed using the Murono score	—

Secondary

Measure	Time frame
1. Visibility of the pyriform sinus 2. Lesion detection rate 3. Observation time 4. Adverse events 5. Patient discomfort	—

Contacts

Public ContactAiji Hattori

Mie University Graduate School of Medicine

aiji-h@med.mie-u.ac.jp+81-592321111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026