Postoperative respiratory failure after cardiac surgery requiring cardiopulmonary bypass
Conditions
Interventions
In addition to standard therapy, CNAP will be applied using the extracorporeal positive and negative pressure ventilator TCV-100K (IMI Co., Ltd., Saitama, Japan).
Sponsors
Yamaguchi Takumi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who underwent cardiac surgery with cardiopulmonary bypass. Patients who were weaned from invasive mechanical ventilation within one week after surgery. At the time of invasive mechanical ventilation weaning, patients with a PaO2/FiO2 ratio > 200 and PEEP 20%. Written informed consent for participation in this study has been obtained from the patient or a legally authorized representative.
Exclusion criteria
Exclusion criteria: Patients younger than 18 years of age at the time of consent. Patients who have undergone surgical procedures involving abdominal incision and who have surgical wounds in the abdominal region. Patients with skin lesions at the intended CNAP application site that make appropriate application difficult. Patients who are pregnant or may be pregnant. Patients in whom, due to physical characteristics or device limitations, the target continuous negative pressure cannot be stably maintained after CNAP application. Patients for whom, at the time of liberation from invasive positive pressure ventilation (IPPV), noninvasive positive pressure ventilation (NPPV) was deemed medically necessary.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the PaO2/FiO2 ratio from the time of extubation to 24 hours after extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| PaO2/FiO2 ratio and respiratory rate at 0, 6, 12, 18, and 24 hours after extubation Rate of reintroduction of noninvasive positive pressure ventilation (NPPV) or invasive positive pressure ventilation (IPPV) by reintubation, and time to event Incidence of skin complications at the CNAP application site | — |
Contacts
Public ContactTakumi Yamaguchi
Department of Anesthesia and Intensive Care, Japnanese Red Cross Aichi Medical Center Nagoya Daini Hospital
Outcome results
None listed