Chronic kidney disease Chronic kidney disease
Conditions
Interventions
1 . Brief nutritional counseling using an informational leaflet on salt reduction.
2. Confirmation and recording of resting home blood pressure (as recorded in a blood pressure diary or equivalent) fo
Sponsors
Iwamo Takuya
Eligibility
Inclusion criteria
Inclusion criteria: 1) Disease and Diagnostic Criteria: Patients with an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m^2. 2) Disease Stage and Type: Patients classified as having CKD stage G3a or higher according to the CKD severity classification. 3) Age: 18 years or older. 4) Home Blood Pressure Monitoring: Patients capable of consistently recording their blood pressure upon awakening (or in the morning) at home using a blood pressure diary or an equivalent record. 5) General Condition: Not specified. 6) Relevant Major Organ Function: Kidney function. 7) Informed Consent: Written informed consent from the patient is required.
Exclusion criteria
Exclusion criteria: 1) Inability to record home blood pressure upon awakening (or in the morning) using a blood pressure diary or an equivalent record. 2) Inability to continuously visit a participating community pharmacy for a period of three months. 3) Difficulty in communication or impaired ability to communicate. 4) Undergoing maintenance dialysis. 5) Morning (or early morning) blood pressure below 90/60 mmHg, or experiencing dizziness due to hypotension. 6) Oral salt intake as a prescribed medication. 7) Addition or dose escalation of antihypertensive medication between the intervention start date and the end of the observation period. 8) Determined to be inappropriate for participation in this study by the principal investigator or sub-investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The mean systolic blood pressure measured during the 7 days prior to the intervention and during the 7 days following the intervention, based on home blood pressure recordings. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Salt sensitivity assessed using Salsave: Mean value across six taste concentration levels (0.6%, 0.8%, 1.0%, 1.2%, 1.4%, and 1.6%). 2. Patient awareness survey regarding salt reduction. 3. Renal function (eGFR). 4. Serum creatinine level and blood urea nitrogen/creatinine ratio. 5. Serum Na Cl difference (as an index of metabolic acidosis). 6. Analysis of factors influencing the success of salt reduction. | — |
Contacts
Public ContactYuki Asai
Mie University hospital
Outcome results
None listed