In vivo PET Study of Synaptic Density and Mitochondrial Function in Bipolar Disorder

Comparative Study of Synaptic Density and Mitochondrial Function in Bipolar disorder and Healthy Individuals Using Positron Emission Tomography

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1042240058

Enrollment

Registered

2024-07-23

Start date

2024-07-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bipolar disorder Bipolar disorder

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Individuals aged between 18 and 50 years at the time of consent 2) Individuals who have provided consent through signing the informed consent form 3) (Applicable only to patients with bipolar disorder) Individuals diagnosed with bipolar disorder according to the DSM-5, the international diagnostic criteria

Exclusion criteria

Exclusion criteria: 1) Individuals with a current or past history of organic brain diseases 2) Individuals with mitochondrial diseases 3) Individuals with coexisting substance-related disorders 4) For women, individuals who are pregnant or may be pregnant 5) Individuals unable to undergo PET due to claustrophobia or similar reasons 6) Individuals unable to undergo MRI due to the presence of metallic implants (such as brain clips or pacemakers) or tattoos 7) (Applicable only to healthy individuals) Individuals with a current or past history of mental disorders

Design outcomes

Primary

Measure	Time frame
SUVR values of [11C]UCB-J and [18F]BCPP-EF in dorsolateral prefrontal cortex in patients with anorexia nervosa and healthy subjects	—

Secondary

Measure	Time frame
1) SUVR values of [11C]UCB-J and [18F]BCPP-EF in brai n regions other than the dorsolateral prefrontal cortex in patients with bipolar disorder and healthy subjects. 2) Psychological and clinical assessments: Evaluation of g eneral mental disorders (SCID), depression assessment (BDI-2), manic aseessment (YMRS), intellectual ability assessment (JART), stress and anxiety assessment (STAI), social and economic status assessment (SES), handed ness assessment (Edinburgh Handedness Inventory). 3) MRI: MRS imaging to measure metabolite concentration s such as GABA and glutamate, resting-state functional M RI to measure functional connectivity, DTI imaging to meas ure neural fiber tracts.	—

Measure

Time frame

1) SUVR values of [11C]UCB-J and [18F]BCPP-EF in brai n regions other than the dorsolateral prefrontal cortex in patients with bipolar disorder and healthy subjects. 2) Psychological and clinical assessments: Evaluation of g eneral mental disorders (SCID), depression assessment (BDI-2), manic aseessment (YMRS), intellectual ability assessment (JART), stress and anxiety assessment (STAI), social and economic status assessment (SES), handed ness assessment (Edinburgh Handedness Inventory). 3) MRI: MRS imaging to measure metabolite concentration s such as GABA and glutamate, resting-state functional M RI to measure functional connectivity, DTI imaging to meas ure neural fiber tracts.

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Contacts

Public ContactMasamichi Yokokura

Hamamatsu University School of Medicine

ykkr@hama-med.ac.jp+81-53-435-2295

Outcome results