Additional fine needle aspiration for peripheral pulmonary lesions accompanied with interstitial lung disease

Phase II study of additional transbronchial needle aspiration to transbronchial biopsy for the diagnosis of peripheral pulmonary lesions in patients with interstitial lung disease

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1042230076

Enrollment

Registered

2023-09-05

Start date

2023-09-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral pulmonary lesions accompanied with interstitial lung disease

Interventions

We perform transbronchial needle aspiration in addition to transbronchial biopsy using endobronchial ultrasonography with a guide sheath (EBUS-GS) to diagnose peripheral pulmonary lesions in patients

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with a peripheral pulmonary lesion who need to undergo diagnostic bronchoscopy 2. 18 years old or older 3. The presence of interstitial lung disease on chest computed tomography 4. The informed consent

Exclusion criteria

Exclusion criteria: 1. Lesion located within the inner third ellipse from the hilum on chest computed tomography 2. Patients needing to undergo diagnotic bronchoscopy for non-target lesion in the same setting 3. Women who are pregnant or may become pregnant 4. Patients who are unable to temporarily discontinue antiplatelet or anticoagulant medications for this study 5. Severe bleeding tendency 6. Other clinical difficulties in this trial

Design outcomes

Primary

Measure	Time frame
The diagnostic yield based on histological or cytological findings via transbronchial biopsy or fine needle aspiration	—

Secondary

Measure	Time frame
1. The improvement rate of Radial EBUS images We classify the positional relation of the R-EBUS probe with the lesion into three groups as follows: a) within, when the probe is located inside the lesion; b) adjacent to, when the probe is located at the periphery of the lesion; c) outside, when the probe is located outside the lesion. We set the improvement of the EBUS images as follows: when the EBUS image of 'adjacent to' changed to 'within' or the image of 'invisible' changed to 'adjacent to' or 'within', the EBUS imaging is considered to have improved. 2. The examination time	—

Measure

Time frame

1. The improvement rate of Radial EBUS images We classify the positional relation of the R-EBUS probe with the lesion into three groups as follows: a) within, when the probe is located inside the lesion; b) adjacent to, when the probe is located at the periphery of the lesion; c) outside, when the probe is located outside the lesion. We set the improvement of the EBUS images as follows: when the EBUS image of 'adjacent to' changed to 'within' or the image of 'invisible' changed to 'adjacent to' or 'within', the EBUS imaging is considered to have improved. 2. The examination time

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Contacts

Public ContactTakayasu Ito

Nagoya University Hospital

takaito9@med.nagoya-u.ac.jp+81-52-744-2167

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026