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TWICE trial

Re-examination of the right colon with narrow band imaging after conventional forward view examination: an open-label randomized control trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCT1042230023
Enrollment
1068
Registered
2023-05-24
Start date
2023-10-10
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal adenomas, colorectal cancer

Interventions

Additional forward view examination in the right colon with narrow-band imaging (Control group) Standard withdrawal colonoscopy group
Standard forward view examination in the whole colon with white-light imaging (Test group) Second forward view with narrow-band imaging group
Second forward view examination of the right colon with narrow-band imaging after the first right-colon examination with white-light imaging

Sponsors

Imai Kenichiro
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Asymptomatic patients undergoing colonoscopy for colorectal cancer screening or polyp surveilance

Exclusion criteria

Exclusion criteria: (1)Prior colonic resection (2)Inflammatory bowel disease, polyposis syndrome (3)Irreversible coagulopathy and thrombocytopenia (4)Pregnant woman (5)Infeasibility of suspending antithrombotic drugs

Design outcomes

Primary

MeasureTime frame
Adenoma detection rate in the right colon

Secondary

MeasureTime frame
Adenoma detection rate of the whole colon Additional adenoma detection rate at the second observation Total number of adenomas detected in each group Adverse events Predictors for adenoma detection rate in the right colon Recommended surveillance interval according to guidelines Performance evaluation of colonoscopy in narrow-band imaging observation Serrated polyp detection rate in the right colon Polyp (adenoma or serrated polyp) detection rate in the right colon Total number of adenomas and serrated polyps detected in each group

Contacts

Public ContactHidenori Kimura

Shiga University of Medical Science Hospital

kimura64@belle.shiga-med.ac.jp+81-77-548-2217

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026