A study to see whether giving amino acids during heart surgery can help protect the kidneys

Evaluation of the Protective Effect of Intraoperative Amino Acid Infusion on Acute Kidney Injury During Cardiovascular Surgery With Cardiopulmonary Bypass

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1041260001

Enrollment

300

Registered

2026-04-01

Start date

2023-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who underwent cardiovascular surgery with cardiopulmonary bypass at Hamamatsu University School of Medicine Hospital between January 1, 2023 and August 31, 2025

Exclusion criteria

Exclusion criteria: 1.Patients in whom hemodialysis has been initiated preoperatively or is planned postoperatively 2.Patients with chronic kidney disease stage IV or higher 3.Cases in which the patient or the patient's legal representative refuses or withdraws participation in this study 4.Cases found after enrollment not to meet the eligibility criteria 5.Patients with an allergy to amino acid preparations

Design outcomes

Primary

Measure	Time frame
Presence or absence of acute kidney injury (AKI), assessed using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria	—

Secondary

Measure	Time frame
Severity of AKI,Duration of AKI,Duration of renal impairment (serum creatinine > 168 mmol/L),Time course of estimated glomerular filtration rate (eGFR),Urine output,Use of renal replacement therapy (RRT),Duration of RRT,Transition to maintenance hemodialysis,Serum urea level,Fluid balance (input-output balance),Duration of oliguria,Use of diuretics,Length of stay in the intensive care unit (ICU),Use of vasopressors,Duration of mechanical ventilation,Reoperation,Change in antibiotics,Atrial fibrillation,Ventricular fibrillation,Ventricular tachycardia,Cardiopulmonary resuscitation (CPR),Stroke,Mortality	—

Measure

Time frame

Severity of AKI,Duration of AKI,Duration of renal impairment (serum creatinine > 168 mmol/L),Time course of estimated glomerular filtration rate (eGFR),Urine output,Use of renal replacement therapy (RRT),Duration of RRT,Transition to maintenance hemodialysis,Serum urea level,Fluid balance (input-output balance),Duration of oliguria,Use of diuretics,Length of stay in the intensive care unit (ICU),Use of vasopressors,Duration of mechanical ventilation,Reoperation,Change in antibiotics,Atrial fibrillation,Ventricular fibrillation,Ventricular tachycardia,Cardiopulmonary resuscitation (CPR),Stroke,Mortality

—

Contacts

Public ContactKenta Asai

Department of Medical Equipment Management

asaken64@hama-med.ac.jp+81-53-435-2985

Outcome results