cough variant asthma cough variant astma, cough, methacholine
Conditions
Interventions
Bronchial smooth muscle contraction by inhalation of provocholine
Dissolve probocholine in physiological saline and prepare two-fold serial dilutions of 0.049, 0.098, 0.195, 0.391, 0.781, 1.563, 3.12
Bronchial contraction by inhalation of provocholine
Sponsors
Kenta Yamamura
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Men and women over 20 years old Adults with no history or symptoms of respiratory illness After sufficient informed consent to participate in this study, the patient's free will to give written consent.
Exclusion criteria
Exclusion criteria: Those with hyperthyroidism Those with cardiovascular disease with bradycardia Those with peptic ulcer disease Those with Addison's disease Those with gastrointestinal or urinary tract obstruction Those with epilepsy Those with parkinsonism Those with vagal hypervagus Those with myasthenia gravis who regularly take cholinesterase inhibitors Those with moderate airflow limitation (%FEV1 <70% or FEV1 <1.5 L) Those who are pregnant or breastfeeding Those who have a fever of 37 degrees or higher Those who have been infected with the new coronavirus within the last month Those who are judged to be inappropriate by the principal investigator or co-investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total cough count for 30 minutes induced by inhalation of provocholine | — |
Secondary
| Measure | Time frame |
|---|---|
| Nothing | — |
Contacts
Public ContactYamamura Kenta
Kanazawa University Hospital
Outcome results
None listed