Study of preoperative oral nutritional supplements after neoadjuvant chemotherapy in esophageal carcinoma

Efficacy study of preoperative oral nutritional supplements after neoadjuvant chemotherapy in patients with esophageal carcinoma

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1041210089

Enrollment

Registered

2021-10-27

Start date

2021-10-27

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal carcinoma Esophageal carcinoma

Interventions

preoperative oral intake of ENORAS Liquid for Enteral Use

oral nutritional supplements

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who treated with neoadjuvant chemotherapy followed by esophagectomy for esophageal carcinoma. 2. Written informed consent.

Exclusion criteria

Exclusion criteria: 1. oral feeding difficulty. 2. Treated with enteral nutrition other than ENORAS liquid for enteral use. 3. History of treatment for esophageal carcinoma. 4. Planed to undergo two-stage operation. 5. Contraindicate for ENORAS liquid for enteral use. 6. Ineligible for the study at the physician's assessment.

Design outcomes

Primary

Measure	Time frame
The factors mentioned below will be evaluated comparing with historical controls. perioperative nutrition indexes GPS: Glasgow Prognostic Score mGPS: modified GPS PNI: Prognostic Nutritional Index CONUT score: Controlling Nutritional Status Score NLR: Neutrophil Lymphocyte Ratio PLR: Platelet Lymphocyte Ratio LMR: Lymphocyte Monocyte Ratio CAR: CRP Albumin Ration Alb: Albumin CRP: C reactive Protein Ch-E: Cholinesterase T-cho: Total Cholesterol Body weight Body composition	—

Measure

Time frame

The factors mentioned below will be evaluated comparing with historical controls. perioperative nutrition indexes GPS: Glasgow Prognostic Score mGPS: modified GPS PNI: Prognostic Nutritional Index CONUT score: Controlling Nutritional Status Score NLR: Neutrophil Lymphocyte Ratio PLR: Platelet Lymphocyte Ratio LMR: Lymphocyte Monocyte Ratio CAR: CRP Albumin Ration Alb: Albumin CRP: C reactive Protein Ch-E: Cholinesterase T-cho: Total Cholesterol Body weight Body composition

—

Secondary

Measure	Time frame
The factors mentioned below will be evaluated comparing with historical controls. Postoperative pneumoniae Postoperative complications Postoperative hospital stays Oral dose of ENORAS liquid for enteral use Diarrhea	—

Contacts

Public ContactDai Shimizu

Nagoya University Hospital

d-shimizu@med.nagoya-u.ac.jp+81-527442249

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026