Esophageal cancer
Conditions
Interventions
Chemoradiation
Cisplatin 75 mg / m2 day 1
Fluorouracil 1000 mg / m2 / day days 1 - 4 (96 hours), 2 courses every 4 weeks
Radiotherapy 1.8 Gy / fr x 23 fr Total 41.4 Gy
Sponsors
Maeda Osamu
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.ECOG PS 0-1 2.Endoscopic biopsy of esophageal primary lesion histologically diagnosed as squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma or basal cell carcinoma. 3. Any of the following based on TNM classification (UICC-TNM 7 th edition) 1) cStage IB 2) cStage II 3) cStage III Infiltration into the trachea at the cervical /cervical chest boundary (T4) is eligible. Excluding other T4. So-called borderline-resectable T4 disease, not clearly diagnosed as T4, is eligible. 4) cStage IV with supraclavicular lymph node metastasis and without other distant metastasis. 4. Adequate organ function.
Exclusion criteria
Exclusion criteria: 1) Clear T4 other than invasion of cervical / cervical gastrointestinal tract esophageal cancer 2) Distant metastasis to other than supraclavicular lymph nodes. 3) Esophagogastric junction lesion of which main lesion is located in the stomach rather than the esophagus. 4) Judged not to be eligible by the researchers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of adveser events, response rate, rate of complete resection, histopathological response rate, histopathological complete response rate, rate of perioperative complication, rate of late complication, rate of severe adverse events, progression-free survival, and overall survival | — |
Contacts
Public ContactOsamu Maeda
Nagoya University
Outcome results
None listed