Research on Improving EV Quality

Study on the Safety Evaluation and Impact Analysis of Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells on Human Embryos

Status

Active, not recruiting

Phases

Phase 2

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1040250208

Enrollment

Registered

2026-03-18

Start date

2026-03-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

IVF patients

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Individuals whose patient background (age, treatment history, egg retrieval conditions, etc.) can be verified through medical records 2. For abnormal embryos, individuals for whom written consent for research use was obtained prior to egg retrieval 3. For normal embryos, individuals for whom the embryos became unnecessary after treatment concluded, and for whom written consent for research use was obtained after the decision to discard them was made 4. Individuals for whom written consent to participate in the study was obtained

Exclusion criteria

Exclusion criteria: 1. Individuals whom the principal investigator or a co-investigator deems unsuitable for inclusion in the study

Design outcomes

Primary

Measure	Time frame
Apoptosis in blastocysts (percentage of TUNEL-positive cells)	—

Secondary

Measure	Time frame
1. Embryonic development 2. Exploratory analysis using RNA-seq (discarded frozen embryos from normal fertilization only) 3. Metabolic stress markers (discarded frozen embryos from normal fertilization only)	—

Contacts

Public ContactHiroki Takeuchi

Mie university Hospital

h-takeuchi@med.mie-u.ac.jp+81-592321111

Outcome results