Longitudinal analysis of surgery-induced sarcopenia for lung cancer patients with air-flow limitation

Longitudinal analysis of surgery-induced sarcopenia for lung cancer patients with air-flow limitation Ancillary analysis of a multicenter randomized phase II trial, RehaBoost - LONG BOOST

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1040250207

Enrollment

Registered

2026-03-16

Start date

2026-03-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer patients with air flow limitation scheduled for surgical treatment

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The following conditions must all be met: (1) The participant is enrolled in the "RehaBoost" trial (IoT based perioperative telerehabilitation intervention for lung cancer patients with air flow limitation, a multicenter randomized phase II trial; jRCTs042230112) and has not withdrawn their consent, including consent for the secondary use of data. (2) Written consent has been obtained from the participant regarding participation in this ancillary study.

Exclusion criteria

Exclusion criteria: (1) Patients deemed unsuitable for this study by the principal investigator (2) Any other individuals deemed unsuitable by the attending physician

Design outcomes

Primary

Measure	Time frame
Identification of biomarkers for postoperative physical activity and intensity associated with the 6-minute walk test distance (change from preoperative levels at 3 months post-surgery) using AI	—

Secondary

Measure	Time frame
AI-driven identification of biomarkers for postoperative physical activity and intensity (6-minute walk test distance [change from preoperative to 6-month postoperative levels], changes in respiratory function, changes in PHR [resting heart rate, VO2max, etc.] obtained from Fitbit Inspire 3, changes in quality of life) AI-based exploration of biomarkers for postoperative complications (preoperative cardiopulmonary function, preoperative physical activity levels and intensity, surgical procedure, presence or absence of remote rehabilitation intervention, etc.) Association between surgical procedure and changes in skeletal muscle mass Association between surgical procedure and pre- and postoperative epigenome (DNA methylation age, etc.) Association between the epigenome (DNA methylation age, etc.) and postoperative complications, skeletal muscle mass, physical activity levels and intensity	—

Measure

Time frame

AI-driven identification of biomarkers for postoperative physical activity and intensity (6-minute walk test distance [change from preoperative to 6-month postoperative levels], changes in respiratory function, changes in PHR [resting heart rate, VO2max, etc.] obtained from Fitbit Inspire 3, changes in quality of life) AI-based exploration of biomarkers for postoperative complications (preoperative cardiopulmonary function, preoperative physical activity levels and intensity, surgical procedure, presence or absence of remote rehabilitation intervention, etc.) Association between surgical procedure and changes in skeletal muscle mass Association between surgical procedure and pre- and postoperative epigenome (DNA methylation age, etc.) Association between the epigenome (DNA methylation age, etc.) and postoperative complications, skeletal muscle mass, physical activity levels and intensity

—

Contacts

Public ContactShinya Katsumata

Shizuoka Cancer Center

shi.katsumata@scchr.jp+81-55-989-5222

Outcome results