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Retrospective multicenter clinical study of the frequency of hyperkalemia in severely renally impaired patients treated with sacubitril valsartan

Retrospective multicenter clinical study of the frequency of hyperkalemia in severely renally impaired patients treated with sacubitril valsartan

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-jRCT1040230154
Enrollment
Unknown
Registered
2024-02-16
Start date
2024-02-29
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure

Interventions

None listed

Sponsors

Watanabe Kozo
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inpatients prescribed SV for heart failure

Exclusion criteria

Exclusion criteria: Patients with malignant comorbidities or diagnosed with malignancy during the SV observation period Patients with a history of SV prescription within 4 weeks prior to the date of first SV prescription Inpatients who are prescribed SV for doses other than twice daily

Design outcomes

Primary

MeasureTime frame
Incidence of the following composite endpoints in the groups of normal renal function, mildly impaired renal function, moderately impaired renal function, severely impaired renal function, and dialysis patients 1) Incidence of serum potassium level grater than 5.5 mmom/L, 2) reduction or discontinuation of SV, reduction or discontinuation of MRA, or initiation or increase of new potassium-binding agents when serum potassium level is above the upper limit of normal

Secondary

MeasureTime frame
1) Incidence of serum potassium level grater than 5.5 mmol/L in each groups of normal renal function, mildly impaired renal function, moderately impaired renal function, severely impaired renal function and dialysis patients 2) The incidence of serum potassium level grater than 5.5 mmol/L with and without concomitant medications

Contacts

Public ContactKozo Watanabe

Yaizu City Hospital

kouzou.watanabe@hospital.yaizu.shizuoka.jp+81-54-623-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026