Delayed drug allergy to Amoxicillin Delayed drug allergy
Conditions
Interventions
None listed
Sponsors
Yasuoka Ryuhei
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients aged younger than 15 years old at recruitment 2.Patients who developed a skin rash during or within 48 hours of the end of use of AMPC/ABPC or antimicrobial agents containing AMPC/ABPC 3.Patients with a confirmed diagnosis of AMPC delayed hypersensitivity reaction 4.Patients with a history of delayed hypersensitivity reactions within 90 days of symptom induction 5.Patients whose caregivers agreed to participate in this study in writing
Exclusion criteria
Exclusion criteria: 1. Patients with severe delayed hypersensitivity reactions 2. Patients who have received systemic administration of steroids within a week 3. Patients with concomitant immune-related diseases 4. Patients with concomitant diseases that may affect the proteome and metabolome, such as metabolic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Group Differences in Supernatant IFN-gamma Concentration of DLST by AMPC in Children with Delayed AMPC Allergy and Normal Children | — |
Secondary
| Measure | Time frame |
|---|---|
| Group Differences in Supernatant IL-2,IL-4,IL-5,IL-10,IL-12,IL-13,granzyme Concentration of DLST by AMPC in Children with Delayed AMPC Allergy and Normal Children Difference in supernatant cytokines (IFN-gamma,IL-2,IL-4,IL-5,IL-10,IL-12,IL-13,granzyme) of DLST by AMPC in the AMPC delayed allergy group between AMPC unstimulated (control) and AMPC stimulated samples. | — |
Contacts
Public ContactRyuhei Yasuoka
Hamamatsu University School of Medicine
Outcome results
None listed